Platelet Concentration and Platelet/Lymphocyte Ratio as Prognostic Indicators in Luminal Breast Cancer

Ratios between the blood cells are indirect measures of imbalance in pro-inflammatory status observed carcinogenesis and have been proposed as accessible feasible biomarkers to predict cancer prognosis. We aim evaluate prognostic significance neutrophil/lymphocyte (NLR), monocyte/lymphocyte (MLR), platelet/lymphocyte (PLR) ratios Brazilian patients with luminal breast (LBC) treated tamoxifen. A retrospective cohort 72 operable LBC patients. Preoperative leukocyte platelet absolute values permitted calculate NLR, MLR, PLR. Area under curve (ROC) determined cutoff value associated relapse death. Univariate multivariate analyses were used assess relationship PLR disease-free survival (DFS) overall (OS). Lower DFS was >297 × 103/mm3 (54 vs. 60.9 months <297, p = 0.04). Platelet > 279 related higher OS (p 0.03). analysis revealed that concentration 0.04) 0.04), but not an independent factor (HR 1.31, 95%CI: 0.42–4.07, 0.65) 1.64, 0.28–9.52, 0.58). Both univariate 0.01) < 191.5 a significant predictor OS/better prognosis 16.16, 2.83–109.25, 0.00). Pretreatment indices (absolute count PLR) predictors PRL OS, being OS.